I'd say so. I'd do it again for sure.
There's not a lot of flat panels back there, they are all pretty ridgid. So the full coverage with the butyl was probably overkill. I do plan to get a mild exhaust, so I am leaning forward to mitigate drone, which is caused by vibration. The butyl should help with that.
The two layers of foam (one on the wall, one on the removable panel) probably made the biggest impact. I've also done all four doors. Truck is definitely quieter. I think some thick MLV glued to the removable panel would probably do just about the same. I say glued to the panel vs the wall so you can cover the vents vs going around them. That's where all the road noise is coming in. I have an extra layer of foam over those.
As far as the work, yeah, it's not fun. But... I already had the doors apart to install speakers/Katzkin inserts and the seats out to have my window replaced, so it just made sense to do it all. I've done just about every vehicle I've owned, so I've got the process down and it goes pretty quick.
After I'm confident I've got the floor board leak fix, I'll do the rest of the truck. I'll have the console out soon for a ambient light install anyway, so again it makes sense to only pull it once.
That was wordy, sorry, but bottom line, yes, do it! Especially if you're adding a sub and removing ANC.
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