Right up front I'll mention, although I was initially having intermittent ANC problems before I changed speakers, the ANC problem has gotten worse after replacing my 6x9s. Now the ANC is generating loud droning noise in conjunction with specific RPMs (eg 1500, 2500). After test driving it is persistent and unacceptable, so I have deactivated the ANC system using this procedure. I will do without the ANC system until I can have it tested by service. UPDATED 5/31/19: Ram service has a TSB to fix the ANC, worked for my system, now I have upgraded speakers AND no hum/drone.
My JL Audio 6x9s arrived and are now installed.
Install: Overall the install was easy after I figured out the door panels (previous post). The speakers themselves fit fine (see wire harness caution next), and I could fit the bushing/spacers on top of the speaker too (these protect the tweeter). I had to tuck/wrap the cable harnesses carefully to the sides of the speaker because if you don't they will hang down in front of the window mechanism... had a scare when testing window movement, my left speaker went out. Turns out the window had snagged the connector and yanked it off. After opening the door panel up, reconnecting the harness, and tucking it to the side everything seems to fit fine.
Sound: The sound is quite good (according to my ears) for a base system upgrade. I'm only a mild audiophile, so YMMV of course. The volume balance between the dash JL 3.5s and the door JL 6x9s is spot-on perfect! I've been experimenting with equalizer and balance settings... so far I find a perfectly centered balance setting works great. I have set the bass and midrange at +4 and the treble at +2 or +3... sounds nice although it depends on the music type I'm listening to. I like bass and vocals, and usually prefer rounding off the treble. I think the JLs have a nice gentle tweeter which is what drew me to them. Not excessively bright.
My bottom line: If you want to do a speaker swap the JL C2 line is a good one to go with for sound quality, as long as you don't mind trimming the 3.5" speaker a bit, being careful with the 6x9 wire harness routing, and if you are ready to potentially DISABLE the ANC system. For me the sound quality was easily worth the hassle, I am a much happier listener now that those 6 flat lifeless stock speakers are gone.