I recently did some experimentation on a 700-mile trip through Indiana and Illinois. Pretty flat with only small grades. I used T/H for a tank and didn't use it for one tank.
In T/H my truck almost never catches 8 th gear, stayed in 7th. Seemed to down shift on the slightest hill. In normal mode, gears changes were actually fewer.
Trans temp stayed the same. Sucked gas both ways. I am sure that in different situations, I will still use T/H to better control the truck, but I have learned that it is not requisite.
It may be that with 3.21 gears, it is advisable to use T/H always. I think a truck properly set up for towing (3.92) may not need T/H in as many situations.
What do you think?