You chose the 3.92 gears, which will reduce the torque load on the transmission and driveshaft, so good move on your part for planned towing. I made the same choice for similar reasons. As
@SD Rebel said, tow/haul mode alters the transmission shift points, and is probably a good choice for hilly areas. I would add that regardless of mode, sixth gear is direct drive in the transmission, using none of the planetary gear sets, so almost no wear or heat is caused. This is the gear you would like to be in for steep pulls, if at all possible. I wouldn't worry about the torque converter, as it locks up at pretty low speed under most conditions, so won't be getting hot. Travel trailers, for the most part, are not very aerodynamic, and I'd be surprised to see MDS kick in on level stretches at highway speed. Downhill, sure, let it go ECO if it wants to. I'll be looking to use my tow/haul and steering wheel ERS buttons to get desired performance. Also, I'm considering an aftermarket finned rear differential cover to help keep the gears cool. And here's words you don't see on here often - slow down a bit. 55 is still legal on most highways and if people want to pass, they'll figure it out. And stop once in awhile to let things cool down. Lots of main roads have designated places where the big trucks pull off to cool their brakes, check tires, etc. You can do likewise.