I can tell you that it takes me weeks of major adjustments, and months of minor adjustments to find my exact right comfortable positions in almost ANY vehicle. But once I did with my Ram, it really is perfect and I feel zero discomfort even on super long drives (like 8+ hours with a couple breaks...still get stiff eventually no matter what, of course).
I have rheumatoid arthritis, so I tend to get stiff/sore/uncomfortable doing any one thing (sitting, standing, walking, running) for less time than it takes most people. So it takes me extra long to find the right spot. But once I did with this truck, it's the second most comfortable driver's seat I've ever been in. My friend's uncle's Cadillac CTS-V PL takes the cake there. Like sitting on a cloud (with a jet engine attached to it lol).