First post here!  Wow.  I read through this entire thread over the last two days.  I  just bought a new 2020 1500 Big Horn with the base 6-speaker system.  I already ordered the Infinity Reference 3032 3.5" speakers to replace the factory dash speakers.  They should be here Saturday and I plan to just work on the project in stages.  
I want to add a 5-8 channel amp and run all the speakers and 1-2 10" subs from that.  In my younger days, I used to install the component sets and make a custom mount for the tweeters in the door.  If I'm reading this thread correctly, I don't think the tweeter will perform very well from the stock system but it should be fine once I install an amp.  I like the idea of having an additional tweeter in the door to provide more high-range that is currently lacking.  The plan is to run new speaker wire from the door speakers whenever I upgrade them and to just leave them hanging.  Sure, I'll have to remove the door panel to connect them but it will make the amp install easier when I get to that point.  This is the component set I am considering for the doors.
	
	
		
			
				
			
			
				
				Reference Series 6"x9" component speaker system
				
					
						
							
						
					
					www.crutchfield.com
				
 
			 
		 
	 
I haven't fully decided on an amp and sub setup.  I would likely fabricate my own box but haven't explored that design or location.  I've been exploring the different ways to properly interface with the stock system.  I don't know which direction I want to go there.  I'm not opposed to running an additional dedicated mono-amp for the sub.  I am not necessarily looking to win any competitions or be heard from half a mile away.  I just like driving with the windows down and having good quality sound which is basically impossible right now.
	
	
		
			
				
			
			
				
				6-channel car amplifier with digital signal processing and Maestro AR interface — 75 watts RMS x 6
				
					
						
							
						
					
					www.crutchfield.com
				
 
			 
		 
	 
	
	
		
			
				
			
			
				
				DSP with Maestro AR amp replacement module — add an aftermarket amp without losing important features
				
					
						
							
						
					
					www.crutchfield.com
				
 
			 
		 
	 
	
	
		
			
				
			
			
				
				AmpPRO 4 Amplifier Integration Interface
				
					
						
							
						
					
					catalog.pac-audio.com
				
 
			 
		 
	 
1.  If I were to run the 3032 in the dash and then the 6x9 component set in the doors, possibly front and back, what kind of power should I be looking at from the amp?  The components handle up to 125w RMS and the 3.5" up to 25w RMS.  
2.  Is a 6-channel the best option for the speakers if I'd be running three sets of speakers? (Dash, front door, rear roor)  Do I consider the 4/5-channel option and not connect the dash speakers if I'm running the 6x9 components with their tweeters in mounted in the door?
3.  I have not run new speaker wire in a car since like 2001.  How difficult is it to run speaker wire in these trucks?
I'm sure I have more questions.  Reading through this has helped a lot and put me on the right track but things are obviously much more difficult than they used to be so I need to make sure I'm making the best decisions.  Thanks!!