I have a 2021 Ram 1500 Laramie 4X4, 5.7 Hemi, 3.92 gears. I have just under 5k miles on it. I'm not unhappy with the truck, but I probably won't keep it.
The interior is built well. Nothing rattles, very little wind noise, and when you push on various components and surfaces they feel durable and don't move. The interior is the best part of the truck. The LED headlights are great. The back seat is enormous for the kids and car seats.
The mileage is abysmal. I know it isn't a Prius, but its gets the worst mileage of every truck I've owned. Due to the recommended 89 octane fuel, the 5.7 Hemi costs more for fuel than a 6.0 gas Silverado 2500 I had. I haven't seen above 18 on the highway. My combined average is never over 14. I don't accelerate hard and I drive Ms. Daisy around town. I live in Arizona where the speed limit is 75 and its not uncommon to run 80 on the highways. I saw low to mid 20's in the MPGs on the highway with a F150 with the 3.5 and the Silverado with the 5.0. My combined average in the F150 was 18. The Ram drinks about 15 more gallons of fuel per month than my F150. In total, the Ram costs me about $55 more a month for fuel than my F150s and Silverados did (about $45 more if I used 87 octane, but I use the recommended 89 octane).
The Ram tows ok. The rear coils sag more than the F150s and Silverados I've had. The back end isn't as stable. If I keep it, I'll be adding stronger coils and a better sway bar. The F150 was definitely the best half-ton truck I've towed with. I have three trailers that I tow occasionally. I stay well under my weights and use quality distribution hitches with sway control. If I had to rank the F150, Silverado, and Ram for towing, they would be from best to worst in that order. I'm not saying the Ram doesn't tow, I just think overall its not as good as the competition.
I don't four wheel the Ram, but I'll drive dirt roads to trailheads. The front end bottoms out fast. The Ford won here, too. The suspension on the F150 felt like a capable truck. The Ram feels like I'm driving a car or crossover on poor condition roads.
The rear end on the Ram started making a grinding noise after 3k miles. Dealer added friction modifier and it fixed it. They said it was common for these trucks to come from the factory without enough friction modifier in the limited slip rear end. I'm not sure that was the issue or if the fluid is masking a different problem. My reason for this is there wasn't a problem until after I towed about 700 miles straight.
I think the Ram is the perfect truck for somebody who needs a car with a truck bed. It rides and handles like a car. It sits about the same height as crossovers and small SUVs. It definitely has a lot of creature comforts for the price. It will work fine for me if I decide to keep it. I bought it because of the good reviews, it works well for my family, I like the looks and interior quality, it's tow rating, and I wanted to try something different than Ford and Chevrolet. I don't regret buying the Ram, but it's not my favorite.
I'm probably going back to an F150 at some point. The F150 interiors are cheaper and they aren't as quiet as the Ram, but overall I like the F150 more than the Ram 1500. To me, the F150 is a truck and I miss that. Ram may have found a new market in crossover trucks with the 2019+ 1500. As for Chevy, I'll stay away until they stop letting descendants of Picasso design their vehicles.