You can never have too much tire.
It will be a personal decision based on budget, use, looks, and feel (the higher the rating the firmer the sidewall...and ride).
My last truck was an HD diesel (7800 lbs empty) with 3.73 in the rear so an E-rated tire was a no-brainer. Since it was a diesel I could easily upsize a bit with no change in performance or economy with 600+ lb-ft on tap at 1600 RPM.
With my 3.21 rear and gas engine I'm not interested in "beefing up" or oversizing. Besides the extra cost I will definitely feel it in the driver's seat (10+ extra lbs of tire to turn) and in my wallet (fuel economy will go down with ~50 extra lbs to keep rotating), even more so if I upsize.
If I had 3.92s in the chunk I would stay OEM-sized but definitely be open to the possibility of an E-rated tire (the Rebel has them) as the shorter gears would offset most of my concerns and give me more than a handful of decent tire choices.