I had this happen to me over the weekend. Pulled into a parking lot and hopped out of the truck and went to lock the doors with the door handle button and it would not work. Pulled the fob out of my pocket and hit the button to lock the doors and it would not work. A few frustrating minutes later I got it to lock via the remote button but then it would not unlock with grabbing the handle. Played games with it for 5 minutes before cycling the truck on and off. Worked ok after that and hasn’t yet acted up again.