I watched that video, I don’t recall a mention of the 3.21 specifically at all. The reviewers spent their time discussing the Hemi and it’s towing power and never really addressed gearing other than to state what each truck was running.I recently returned from a cross country drive with some sizable mountain climbs and descends. I tended to drive a few over the listed speed limits of between 65 to 80mph and saw 17.5mpg to 18.8 mpg. I'm happy with that.
I'd much rather have the 3.92's added tow capability than the 3.21's marginal mpg improvement. The recent TFL truck utube video comparison between a 2019 Hemi Rebel 3.92 and the 2020 ED with 3.55 makes a strong argument to steer clear of 3.21 if you plan to tow/haul.
After owning both, I don’t see a big difference between the two at all. Those in favor of mileage may believe they are going to save big on gas with the 3.21...they aren’t. Those in favor or torque may believe they will benefit big with 3.92...they won’t.