Adrianp89
Ram Guru
The 3.92 will have more wear and tear, worse gas mileage, and more noise and vibration in the cab at highway speeds.
Oliver392 hit the nail on the head. My buddy has the same truck with 3.92, I have 3.21. off the line there is barely a difference. The 8sp trans makes the gear ratio much less of a factor since there is always a good gear to go to.
My biggest reason for getting the 3.21 was longevity. No matter what anyone says, 500 revolutions per minute more adds up to alot more spinning of parts over the truck's lifetime. I see no reason to have your engine turning 2k instead of 1500 while driving down the highway. I only tow a medium sized boat and only do it occasionally, but I've never had an issue with power with the 3.21's.
Unless you are towing a significant amount of weight a significant amount of the time, there is no reason to get the 3.92 unless you are planning on drag racing everyone.
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Coming from the 3.21... the 3.92 "feels" a lot quicker and more fun to drive across the band. That alone is enough reason to get the 3.92, and is why I got a truck with it.