E85 is about $1 cheaper a gallon than 87 here in pa. So the lower mpg is a wash when it comes to cost.
As far as e15. I’ve ran several tanks of it, 87, and 89. Didn’t bother with 91. But They are all a wash when it comes to mpg differences. I still get my window sticker mpg averages with e15 and none of the pinging you get with 87, whether it’s 10% e or pure gas. Same results in my ecoboost focus which suffers some pretty bad pinging on 87 when the ambient temp is above 90
As stated by a previous poster, mpg isn’t affected