If your tuner tuned for it, that's a different story.Have to agree here. If you have a 220 that and you are hitting 250, well it is open at 220, so what difference does it make if it opens at 180? It is still circulating 250 coolant.
That said, while my truck is a slow mass produced pickup truck like you guys drive I leave it stock for that reason, my car has a 180 Stat. Why? Because while they had it apart putting in a cam, I replaced all the other parts. And the tuner said I should. So what's another $20?