I gave you my reason

The truck shifts excessively (and needlessly). When you come up to a hill you can give a little gas to gain speed, climb the hill and let it bleed down a bit, coast down the other side, without a single shift (or using 1 instead of 2 or 3 etc). The CC will do whatever it can to keep you at speed as you climb the hill, but it won't see the hill coming and it won't slowly boost your speed, when it finally bites on the hill its too late and there goes the engine screaming away trying to hold 65 (or whatever); but if you do it manually and "run at it", you can hit the beginning of the hill at 70+ let the hill bite while you don't give it anymore gas (no downshifts) and bleed down to 55 at the top all without a single shift.
It's harder to explain than it is to just try it out, you might like it better without CC. Don't fixate on the numbers above, it's just an example, but the technique works very well.
And obviously it depends on the hill as well, some hills are going to require a downshift regardless, but even there you can choose to back down your speed and let it rev at lower rpms vs the "blind as a bat" CC which insists on screaming away because that's the speed you set it at.
In 4 words: you have more control.