So I just took the Ram for a 4 hr round trip and managed 21.6 overall average MPG. This was on the freeway for the most part.
A few things I noted:
1. Speed, with my setup 4x4 w/ 3.92 64-66 mph is the sweet spot for the best MPG.
2. Wind/aerodynamics these new Rams are not the most aero friendly, and this only worsens with more speed. Only way around this is reducing speed.
3. Acceleration is hard for me as I like to get up to speed swiftly, but I took my time getting speed and my MPG reflected that. *Note, this is not always practical due to traffic and such*
Side note, if you really want to see some great MPG find a truck/suv to follow and watch how much your MPG will increase. You don't need to tailgate, just a nice average distance and it makes a huge difference.