Yes.
The height of the truck changes the canter (I think is what its called) of your wheels.
Essentially if you go up or down you ride on the inside and outside of your tires respectively.
If you were driving 75mph in off road 2 you would be putting a lot more wear on the outside of your tires, driving in entry-exit would wear the inside.
You CAN make adjustments to the air suspension settings, I think you could make normal similar to off-road1, but you would want to get an alignment or spaces or somehting I don't know, I just know it will wear the tires and can drive funky.
Someone else will likely chime in and explain better then me.