Highly recommended 4x4 over 4x2. The truck will be 4x2 most of the time regardless anyways, and you never know when you'll need it. I live in an area that requires it. Also a Limited, so long as you're in the US, you'll have air suspension standard and can lower it a little to help fit in the garage. Also, having 4x4 only increases height by .1 inches. A 10th of an inch, 77.6 inches over 77.5 inches in exterior body height. Adding the 4x4 Off-Road Group adds a 1 inch lift on top of that if you get it like mine, but that means only 1 Off-Road Air Suspension Height Setting rather than 2 settings. You want higher MPG: get a smaller axle ratio [3.21 over 3.92], smaller wheels, all-seasons, and if you're like me, the EcoDiesel. Otherwise, a 5.7L Hemi 1500 with all the stuff you get in a Limited, expect 15-17 mpg avg; 4x4 or not; which blows but ya know.
Also, we also pull a horse trailer; but a 1500 is too small for it; my max towing is about 9k lbs on my new 1500 and our horse trailer empty is 10k lbs. It's a 3 horse trailer but we almost always only have 1 horse in it. We pull it with a '20 2500 Big Horn Night Edition 6.4L Hemi V8. Max towing is about 14k lbs. My point is, just keep in mind all the other capacities for your weights: tongue weight, payload, etc. Maybe look into HD's; that is of course if its a larger size trailer. Was also carrying like 20 feed bags in my 1500 the other day and was like 400 lbs overweight; the higher the trim and the more packages, the less stuff you can haul or tow obvi; but 4x4 is still a must imo.
Really recommend the Anti-Slip or Electronic Locking Rear Axle [Now only available as a part of the Off-Road Group and no longer as a standalone option] also.
And yes resale value; at least in my area; of the 17,000 new trucks in my area of all brands and types; 200 are 2WD/RWD only. Not having 4x4 never made any sense to me; why buy a 4x2 truck when you can get a 4x2 Truck with 4x4 capability?