I drove about 155 miles a day one way for 4 years on a nearly new car. Almost all highway, maybe 10 miles max on 45 mph city streets, the rest was 65-70 mph on I-40. Car sat for the 8-9 hours I worked then 155 back. That was about 148K. Then I quit that job and found something like 8 miles one way.
Car has close to 200K on it now and the highway driving was certainly easier on it than the city. I never replaced the struts, shocks, brakes or suspension components in the 148K, but have had to do all of those in the subsequent 50K of city driving.
I’d take a documented oil/fluid changed high mileage low years vehicle any day over the “average” mileage city commute car. JMHO of course.