Found a calculator that will allow you to compare the annual cost of fuel for two different cars or two different fuels.
Here what I found for my truck using E-10 / 89 octane fuel vs running Non-Ethanol fuel 90 octane.
The truck averaged 17 MPG on the ethanol fuel due to the lower BTU's ( ethanol has 30 percent less energy than gasoline).
I averaged 20 MPG on the non-ethanol fuel driving the same route to work every day.
Actually saved a little money over the long term even though I paid more at the pump. I was able to drive more miles on the non-ethanol fuel.
I also noticed that the truck seemed to go into ECO mode easier which I believe led to better MPG.
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Here is the link to the calculator:
http://calcnexus.com/fuel-cost-calc...ce1=2.674&price2=3.169&mpg1=17&mpg2=20&calc=1