Bigger sidewall is GENERALLY going to give better ride softness.
Ride QUALITY is generally an opinion based on what one finds quality...so to speak.
If one determines quality to be that they corner tightly and feel every swell and bump of the road that they can, then they will probably like lower profiles....
If one thinks quality is is more of a thud and bounce over bumps, and more absorption, then they might be keen on fatter walls.
Quality to me is about absorbing the road.
Some may feel quality is how long a tire lasts, maybe also coupled with other attributes like mentioned above.
Lower profiles, like 22s will GENERALLY be done faster than 20s... and they can cost more. Thats a double whammy. Triple whammy if you throw in how much rougher and unforgiving they can tend to be on rougher roads. Its a quadruple whammy if you throw in the cost of accidental curb rash on rims due to the smaller wall.