If you have smooth roads, you probably couldn't tell, I live in Oklahoma and the roads are garbage, no difference in how the overall diameter of the tire and wheel fill the wheel well, a 33 inch tall tire is 33 inches regardless if it is on an 18, 20, or 22 inch rim.I have driven both, on essentially the same Limited trucks, and I could tell zero difference in ride on the 22's. It is an entirely cosmetic difference, which I like. The wheel opening are huge and the 22's fill them much nicer. The selection of tires for 22's is not as vast, but then again, there are plenty of options.
Lot's of guys with 22's have gone with larger tires as well, which looks even better on these trucks.