I don't have a long commute most days, but I do a lot of 180+ mile round trip weekends with the in-laws, and we never drive my wife's car anywhere.
I haven't owned a vehicle that got more than about 22 mpg in the last 12 years, and I've had many sedans, a wagon, and a smaller truck in that time.
The only time I've even considered the gas mileage was when I was switching from a VW Jetta to an Infiniti M45 back in 2008, when premium unleaded was $4.25 a gallon! Even then, I calculated the big V8 would cost me something like $20-30 a month more in fuel. Well worth it for the luxury upgrade.
As for the RAM, I was coming from a 2010 Ford 4.6L, so I get a lot more power out of the Hemi with no change in efficiency. To answer your question, yes I would still be driving my Longhorn as a daily commuter regardless of distance. It's comfy, luxurious, safe, and nobody complains if they have to ride to lunch in the back seat. Plus it still hauls the kids and the dog and their gear to grandma's, it's great for weekend mulch or home project tasks, and it'll tow the odd boat or trailer as needed. I've got the 33 gallon tank, too, so I don't even think about filling up these days.
You're obviously going to get the most biased answers from this forum, but I'm not purely a truck guy. I just think this truck is a great all around vehicle choice. Only other consideration for commuting would be for me to spend a bit less on a nice Laramie and then pick up a cheap 10-year-old Lexus LS or something for the commutes. Wouldn't save me much on gas, of course.