I recently took a 2500+ mile trip through TX, NM, CO, KS, OK, and the final average was 15.9, per the trip computer. This is a 4WD Limited with 3.21 gears, 22's, at least 89 octane, no towing, one passenger + luggage. Also worth noting, the trip started during the break-in period, there was plenty of 2-lane passing, idling, 40 to 100+ degrees F, some heavy rain, and mountain driving. Given the range of speed limits in each city/state, this could have been anywhere from 55 to 80mph+. So I suppose you could call this a "worst-case scenario," but it isn't too far off from many of my trips. Certainly lots of variety!
If you're cruising under 60, I could totally see getting over 20mpg. But at 70+, that's not happening. That's mostly due to the trans frequent downshift when you hit any incline. There just isn't enough power to hold 8th or sometimes even 6/7. So I'm not totally sold on 3.21 gears if your "highway" speeds are on the higher end of the speedo. Flat roads, lower highway speeds, absolutely.
I'd love to see what the RAM could do with the new V6, or perhaps a couple of extra gears, at some point.
Unimpressive fuel economy and power aside, the ride and handling was easily the most comfortable I've had in a long time. Whether long stretches of empty highway or winding mountain roads, it handled it better than some more expensive luxury vehicles I've had. Comfortable seats, decent stereo, useful tech, plenty of room, etc. Overall, great trip.