WXman
Ram Guru
Same for me. I can't find any conclusive evidence that MDS is detrimental to engine life, but common sense says it's not helping. I deactivate it every time.
Before the 5th Gen trucks came out, there was a lot of discussion on this among the Hemi owners out there. Basically the engine failures from MDS came from two different causes. One was that when MDS is on, you've got 4 cylinder that are "cold" and 4 that are "hot" and that causes issues over time with the engine block and heads and metallurgy of the two. You've got metals contracting and expanding in different ratios inside the same block of material, and that's not good. Secondly, when MDS kicks in there is a jolt to the valvetrain. It happens so quickly on and off and on and off that it delivers a bit of a shock to the components.
The cars with this engine had a recall about ten years ago because this jolting was actually snapping the timing chain/guides and wiping out engines. The assumption was that guys with Challengers and Charger were more likely to go WOT and romp on the pedal, so those engines saw the MDS shock more severely.
Unfortunately, MDS engines have totally different lifters so removing the system requires opening the engine. On my 2011 Challenger I have MDS permanently deactivated via tune. This seems to work well. On my Ram I do what you do and turn it off by entering ERS mode every time I drive.