I have the V6 and just went over 5,000 total miles on a long trip. The trip was 1,000 miles each way. On the way out I was not in a hurry and cruised at a maximum of about 73mph (using cruise). I got 24.7 and 25.9 on two tanks doing that (not from the on board computer, calculated just now in a spreadsheet). Coming back I was trying to pick up my doggie and went faster when possible (cruise normally on 75 or 76 mph sometimes faster to keep up with traffic). I got about 22 mpg doing that (21.7 and 22.6). The furthest I went on a tank was 591 miles (took almost 24 gallons to fill the tank). I have the 3.21 rear end and my truck is 2WD.
It makes sense to me that how fast you go is important since the air resistance of trucks is high due to greater ground clearance and large frontal area. I have a tonneau cover.
The reason the mileage of a truck will be worse with the tailgate down is due to the air resistance. It is the difference between the air force in front of the truck and behind the truck. When you lower the tailgate, you reduce the area of the back of the truck reducing the force from the air pushing the truck forward. The tonneau cover helps by reducing turbulence which reduces the pressure in the air reducing the force on the back of the truck. If it helps you accept what I am saying, I am a mechanical engineer (retired). You cannot prove small effects like this using the truck's calculations. The truck's computer is measuring fuel flow with a relatively low accuracy instrument. The truck should be viewed as a rough indication capable of something like plus or minus 1 mpg at best (that number is my guess). I've seen numbers as high as 28mpg in my truck (average, not instant).
I don't think my single tank mpg I quote above is exactly true either due to variability in when the pump shuts off (I don't trickle in more after it shuts off). But I think it's more accurate than the truck's calculations. Probably good to something like plus or minus 0.5 mpg. Long term, my spreadsheet calculations are much more accurate because the pump variability evens out. My mileage over 5204 miles is 22.01. It will probably go down since I have no long trips planned but probably not a lot, it was 21 mpg before I left.