Here is my observation. Rebel with 3.92 gears and eTorque Hemi. MPG on window sticker says 22 on the highway. In real world, I never can get better than 19 mpg. But I did some not-close-to-real-life tests and I was able to get 22 mpg on the highway constantly.
I-90 from Seattle to Spokane. If you drove there, you know that you need to pass the mountain ridge (Snoqualmie Summit), and then landscape becomes pretty flat. So what I tried:
1. Go 60 mph in the 70 mph speed zone. Other truck drivers were looking at me like I don't know how to drive my truck. But that is still considered "highway speed" my EPA.
2. Use regenerative braking going down the hill after passing the highest point of the mountain ridge to stay at 60 mph and not accelerating further. In 30 minutes I'm pretty sure the battery is 80%+ charged.
3. Then you drive on almost perfectly flat interstate. Still going 60 mph. Eco mode stays on, while without fully charged battery it works on 60 mph only if you are going slightly down the hill. The biggest benefit of eTorque for me that it allows Hemi to stay in Eco (4-cylinder) mode longer.
4. I reset fuel consumption meter on the screen at that point.
After an hour of driving on flat road at 60 mph on 8th gear with Eco mode turned on all the time, I CONSTANLY get 21.5-22.2 mpg, depending on wind conditions. I also was able to repeat same trick in other places where you go down the hill for some time and then drive on the flat road 60 mph - same results. So FCA wasn't actually lying that EPA rating on a highway was 22 mpg with eTorque. That was just a very synthetic test that they've submitted to EPA commission, and they didn't lie.
Will you go on the interstate in perfect no-wind, no-rain, no-snow conditions 60 mph in 70 mph zone? I don't think so. Does that 22 mpg last long? No, as soon as battery charge is depleted in ~1 hour, Eco mode will turn off.
In theory, you will get to a higher speed on 3.21 gears on the same RPMs on 8th gear than I get to drive 60 mph on 3.92 gears. But I don't think that it will make a difference, since I believe that air resistance is killing MPG, not higher RPMs. 3.21 gears will not create enough power to the wheels to constantly have Eco mode turned on at 60 mph. But I haven't checked that fact.