Is Suspension Travel Considered in Tire Size Selection?

[DavidNJ]

In discussing whether a specific wheel and tire size fit it seems the analysis is always done on an empty or near-empty truck that is parked. Isn't what counts is whether it will have interference when it is at full bump against the bump rubbers/jounce stops and at full lock right/left in front? Is part of the reason these are not being looked at because the trucks won't be used for heavy loads, heavy towing, or significant off-road use? Do the trucks used for heavy loads, heavy towing or off-road look at tire size selection differently?