I have a fairly similar situation....in sales, and lots of highway. I average 52K+ miles/year. In Feb 2021 I bought a fairly highly-optioned 2019 Laramie CC Hemi 4x4 that had 17K on it. I opted to forgo the warranty, instead banking the money. I just turned 52K on it yesterday. On probably 70% of my tank fills I hand-calculate and can reliably count on an average of 20.9MPG for mostly highway trips. I've had zero issues so far. I love the comfort and the Laramie suits me well...I like the creature comforts!
I came out of a loaded Jeep Grand Cherokee with the EcoDiesel. Loved it, but did the math using my real world experience and I'm in a Hemi now because I do not believe the fuel savings outweigh the potential issues with the EcoDiesel. (Yes, I know I had a gen2 vs gen3).
This truck is super comfortable...I drove 12 hours straight last Tuesday and then returned in two 6-hour stints over the weekend...ZERO complaints.
Others my disagree, but a good friend has a similar Limited and he complains about his fuel mileage. I do wonder if that is weight-related...his is fully optioned.
FWIW - I'd recommend the Safety group, if only for the adaptive cruise control. The lane-keep is OK, but not great. I got the 12" screen and have really grown to love it. This is the first vehicle in many years that doesn't have a sunroof and I have to say I really do not miss it all. Also, the surround-view camera system is awesome.
Lastly I don't agree with the V6 Pentastar suggestions...the Hemi will hold its value way better and provides enough other benefits to offset the fuel savings.
Good luck!